Technique Delivers HIV Drug Directly to Brain
In a study published in Nature Communications, researchers from Florida International Univ.’s Herbert Wertheim College of Medicine describe a revolutionary technique they have developed that can deliver and fully release the anti-HIV drug AZTTP into the brain.
Madhavan Nair, professor and chair, and Sakhrat Khizroev, professor and vice chair of the HWCOM’s Department of Immunology, used magneto-electric nanoparticles (MENs) to cross the blood-brain barrier and send a significantly increased level of AZTTP — up to 97 percent more — to HIV-infected cells.
Read more: http://www.laboratoryequipment.com/news/2013/04/technique-delivers-hiv-drug-directly-brain
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Here’s a look at the some of the weirdest genetically engineered plants and animals already in existence — and many that are coming your way soon
“I am always surprised how some interviewees tend to trail off towards the end of an interview instead of finishing strong and leaving a lasting impression,” says Zachary Rose, CEO and founder of Green Education Services, a green jobs training firm in New York City. Whether you’re a senior preparing for campus recruiting or a recent graduate still hunting for a job, here are the top questions experts recommend asking at the end of a job interview to leave a great final impression on hiring managers and establish yourself as a top candidate.
“Is There Any Reason Why You Wouldn’t Hire Me?”
Kelsey Meyer, senior vice president of Digital Talent Agents in Columbia, Mo., says, “A recent candidate asked, ‘If you were to not offer the job to me, what would be the reason?’ This was extremely straightforward and a little blunt, but it allowed me to communicate any hesitations I had about the candidate before he left the interview, and he could address them right there.”
“This one question is something I would suggest every single candidate ask,” adds Meyer. It lets you know where you stand and if you need to clarify anything for the interviewer. “If you have the guts to ask it, I don’t think you’ll regret it,” she says.
Rachel Dotson, content manager for ZipRecruiter.com, says, “All too often you hear about candidates leaving an interview and thinking they aced it, only to get a swift rejection email soon after. Take the time while you’re face-to-face to ask about and dispel any doubts that the hiring manager has.” Make sure a key asset of yours hasn’t been overlooked.
“As an Employee, How Could I Exceed Your Expectations?”
Michael B. Junge, a staffing and recruiting industry leader with Irvine Technology Corp. in Santa Ana, Calif., and author of “Purple Squirrel: Stand Out, Land Interviews, and Master the Modern Job Market,” says that one of his favorite interview questions is when a candidate takes the lead and asks, “If I were offered this position and joined your company, how would you measure my success and what could I do to exceed your expectations?”
“The question shows confidence without being overly brash, while also demonstrating that you have an interest in delivering positive results,” Junge adds. What’s more, the answer you receive can reveal what the interviewer hopes to accomplish by making a new hire, and this information can help you determine whether to accept the position if you get an offer.
“How Could I Help Your Company Meet Its Goals?”
Dotson also suggests job candidates ask the interviewer, “How does this position fit in with the short- and long-term goals of the company?” The response to the short-term side of the question gives you further insight into your potential role and helps you tailor the remainder of the discussion and your interview follow-up, she says. “Second, by bringing up long-term goals, you are telling the hiring manager that you’re there for the long-run, not just another new grad that is going to follow suit with her peers and job-hop every six months,” Dotson says.
Junge also recommends that interviewees ask, “What challenges have other new hires faced when starting in similar roles, and what could I do to put myself in a better position to succeed?” He says few students or new grads will ask this question because most haven’t witnessed failure. To a hiring manager, this question demonstrates maturity and awareness, and if you’re hired, the answers can help you avoid the pitfalls of being new.
“What Excites You About Coming into Work?”
Murshed Chowdhury, CEO of Infusive Solutions, a specialized staffing firm in New York City, suggests that candidates ask the interviewer, “What excites you about coming into work every day?”
“This is a role reversal question that we often suggest candidates ask,” he says. People love the opportunity to talk about themselves, so this question provides an excellent chance to learn about the hiring manager and find ways to establish common ground. “This is also a great opportunity for the candidate to determine whether he/she is excited by the same things that excite the hiring manager to see if the culture is a good fit,” Chowdhury adds.
The Bottom Line
Although it is important to provide a great first impression to a potential employer, as well as acing the basics of a job interview, closing the interview strong is just as important.
“Prove to your interviewer that you want this position and you are in this for the right reasons, not simply to fill your day with something to do,” Rose says. Ask these questions before you leave, and leave your potential new employer with a great impression.
As an entrepreneur focused on how to grow your business, taking the time to develop a sleep routine is probably the last thing on your mind. But some sleep advice simply can’t be ignored without paying the price in productivity. Deprive yourself of quality sleep long enough and you’ll wind up chipping away at your business and health.
Here are three bad habits you’ll need to break, if you want to improve the quality of your sleep:
Bad Habit #1: You pull all-nighters then oversleep on weekends.
You’ve likely heard you should go to bed and get up at the same time every day to help optimize your sleep. It is advice entrepreneurs often ignore because they’re busy burning the midnight oil and think they can compensate later. Think again. Experts say it’s critical to keep a target sleep time in mind — even if it’s midnight — then meet it consistently.
Why is this so important? Our bodies are extra sensitive to conditioning, says Daniel Taylor, associate professor of Psychology at the University of North Texas in Denton, Texas. When you go to bed and wake up at drastically different hours, you disturb your circadian rhythm—the 24-hour cycle linked to brain activity, hormone production and cell regeneration.
“It’s like living on the east coast for the week, flying to the west coast for the weekend and then turning back around and flying back to the east coast on Sunday night,” says Taylor. “If you do that every weekend, you’re going to have problems.”
Bad Habit #2: You check email in bed.
Your bed should be used for sleep and sex — that’s it, says William Kohler, medical director of the Florida Sleep Institute in Spring Hill, Fla. “The brain likes routine,” he says. “When the eye sees the bed, it should be associated with sleep, not activity.”
If you can’t get to sleep for more than 15 or 20 minutes, Kohler suggests you get out of bed. Lying around obsessing about ideas for your business is not going to help you fall asleep. In fact, you’re conditioning your brain to be awake in bed. Instead, get up and write those thoughts down on paper or maybe read a book, but don’t lie down again until you’re good and ready to sleep.
Bad Habit #3: You never unwind before bed.
You can’t expect to fall asleep quickly when you try to go straight from work-mode to bed. Taking at least an hour each night to unplug from your day can help you sleep more soundly, says Taylor. You could use that time to take a hot shower or bath.
In fact, slightly increasing your body temperature within an hour of bed can help you get a better night of sleep, says Michael Perlis, associate professor of psychology and director of the Behavioral Sleep Medicine Program at the University of Pennsylvania. A 2008 study by researchers out of the Netherlands Institute for Neuroscience found that a slight increase in skin temperature before bed helps people shift into deeper stages of sleep. Of course, you should also follow the standard advice of keeping your room cool too, since the body’s temperature decreases when you’re snoozing.
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